Topological thermal instability and the length of proteins

نویسندگان

  • R. Burioni
  • D. Cassi
  • F. Cecconi
  • A. Vulpiani
چکیده

We present an analysis of the role of global topology on the structural stability of folded proteins in thermal equilibrium with a heat bath. For a large class of single domain proteins, we compute the harmonic spectrum within the Gaussian Network Model (GNM) and we determine the spectral dimension, a parameter describing the low frequency behaviour of the density of modes. We find a surprisingly strong correlation between the spectral dimension and the number of aminoacids of the protein. Considering that the larger the spectral dimension, the more topologically compact is the folded state, our results indicate that for a given temperature and length of the protein, the folded structure corresponds to the less compact folding compatible with thermodynamic stability.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Topological thermal instability and length of proteins.

We present an analysis of the effects of global topology on the structural stability of folded proteins in thermal equilibrium with a heat bath. For a large class of single domain proteins, we computed the harmonic spectrum within the Gaussian Network Model (GNM) and determined their spectral dimension, a parameter describing the low frequency behavior of the density of modes. We found a surpri...

متن کامل

Modulational instability of dust ion acoustic waves in astrophysical dusty plasmas with non thermal electrons

  Propagation of dust ion acoustic waves in plasmas composed of nonthermal distributed electrons and stationary dust particles is investigated. Nonlinear Schrdinger equation is derived to describe small amplitude waves, using the reduction perturbation technique. Modulation instability of dust ion acoustic waves is analysed for this system. Parametric investigation indicates that growth rate of...

متن کامل

QSPR study on benzene derivatives to some physico-chemical properties by using topological indices

QSPR study on benzene derivatives have been made using recently introduced topological methodology. In this study the relationship between the Randic' (x'), Balaban (J), Szeged (Sz),Harary (H), Wiener (W), HyperWiener and Wiener Polarity (WP) to the thermal energy (Eth), heat capacity (CV) and entropy (S) of benzene derivatives is represented. Physicochemical properties are taken from the quant...

متن کامل

Optimization of Thermal Instability Resistance of FG Flat Structures using an Improved Multi-objective Harmony Search Algorithm

This paper presents a clear monograph on the optimization of thermal instability resistance of the FG (functionally graded) flat structures. For this aim, two FG flat structures, namely an FG beam and an FG circular plate, are considered. These structures are assumed to obey the first-order shear deformation theory, three-parameters power-law distribution of the constituents, and clamped bounda...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2003